Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
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Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Contents
The amyloid cascade hypothesis posits that the initiating event in Alzheimer's disease (AD) is the aggregation and deposition of the β-amyloid (Aβ) peptide, which is a proteolytic cleavage product of the amyloid precursor protein (APP). Mounting evidence suggests that the formation and spread of prion-like Aβ aggregates during AD may contribute to...
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Full title
Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
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TN_cdi_doaj_primary_oai_doaj_org_article_e8779bde378d4e898068a96d4935bbd0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e8779bde378d4e898068a96d4935bbd0
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-018-0529-x
