The NHance® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and A...
The NHance® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients
About this item
Full title
Author / Creator
Aftimos, Philippe , Rolfo, Christian , Rottey, Sylvie , Barthélémy, Philippe , Borg, Christophe , Park, Keunchil , Oh, Do-Youn , Kim, Sang-We , De Jonge, Natalie , Hanssens, Valérie , Zwanenpoel, Karen , Molthoff, Carla , Vugts, Daniëlle , Dreier, Torsten , Verheesen, Peter , van Dongen, Guus A.M.S. , Jacobs, Julie , Van Rompaey, Luc , Hultberg, Anna , Michieli, Paolo , Pauwels, Patrick , Fung, Samson , Thibault, Alain , de Haard, Hans , Leupin, Nicolas and Awada, Ahmad
Publisher
Basel: MDPI AG
Journal title
Language
English
Formats
Publication information
Publisher
Basel: MDPI AG
Subjects
More information
Scope and Contents
Contents
Dysregulation of MET signaling has been implicated in tumorigenesis and metastasis. ARGX-111 combines complete blockade of this pathway with enhanced tumor cell killing and was investigated in 24 patients with MET-positive advanced cancers in a phase 1b study at four dose levels (0.3–10 mg/kg). ARGX-111 was well tolerated up to 3 mg/kg (MTD). Anti-...
Alternative Titles
Full title
The NHance® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients
Authors, Artists and Contributors
Author / Creator
Rolfo, Christian
Rottey, Sylvie
Barthélémy, Philippe
Borg, Christophe
Park, Keunchil
Oh, Do-Youn
Kim, Sang-We
De Jonge, Natalie
Hanssens, Valérie
Zwanenpoel, Karen
Molthoff, Carla
Vugts, Daniëlle
Dreier, Torsten
Verheesen, Peter
van Dongen, Guus A.M.S.
Jacobs, Julie
Van Rompaey, Luc
Hultberg, Anna
Michieli, Paolo
Pauwels, Patrick
Fung, Samson
Thibault, Alain
de Haard, Hans
Leupin, Nicolas
Awada, Ahmad
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f221f0cc086e421e96736936b19db3e0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f221f0cc086e421e96736936b19db3e0
Other Identifiers
ISSN
2227-9059
E-ISSN
2227-9059
DOI
10.3390/biomedicines9060665
