BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through i...
BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking
About this item
Full title
Author / Creator
Tran, Sharon , Juliani, Juliani , Harris, Tiffany J. , Evangelista, Marco , Ratcliffe, Julian , Ellis, Sarah L. , Baloyan, David , Reehorst, Camilla M. , Nightingale, Rebecca , Luk, Ian Y. , Jenkins, Laura J. , Ghilas, Sonia , Yakou, Marina H. , Inguanti, Chantelle , Johnson, Chad , Buchert, Michael , Lee, James C. , De Cruz, Peter , Duszyc, Kinga , Gleeson, Paul A. , Kile, Benjamin T. , Mielke, Lisa A. , Yap, Alpha S. , Mariadason, John M. , Fairlie, W. Douglas and Lee, Erinna F.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes that orchestrate autophagy initiation and endocytic trafficking. Here we show intestinal epithelium-specific BECLIN1 deletion in adult mice leads to rapid fatal enteritis with compromised gut...
Alternative Titles
Full title
BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking
Authors, Artists and Contributors
Author / Creator
Juliani, Juliani
Harris, Tiffany J.
Evangelista, Marco
Ratcliffe, Julian
Ellis, Sarah L.
Baloyan, David
Reehorst, Camilla M.
Nightingale, Rebecca
Luk, Ian Y.
Jenkins, Laura J.
Ghilas, Sonia
Yakou, Marina H.
Inguanti, Chantelle
Johnson, Chad
Buchert, Michael
Lee, James C.
De Cruz, Peter
Duszyc, Kinga
Gleeson, Paul A.
Kile, Benjamin T.
Mielke, Lisa A.
Yap, Alpha S.
Mariadason, John M.
Fairlie, W. Douglas
Lee, Erinna F.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fc863b699bb647f5926120d1c9e15000
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc863b699bb647f5926120d1c9e15000
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-024-05890-7
