Ex-527 inhibits Sirtuins by exploiting their unique NAD⁺-dependent deacetylation mechanism
Ex-527 inhibits Sirtuins by exploiting their unique NAD⁺-dependent deacetylation mechanism
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Sirtuins are protein deacetylases regulating metabolism and stress responses. The seven human Sirtuins (Sirt1–7) are attractive drug targets, but Sirtuin inhibition mechanisms are mostly unidentified. We report the molecular mechanism of Sirtuin inhibition by 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (Ex-527). Inhibitor binding to pote...
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Full title
Ex-527 inhibits Sirtuins by exploiting their unique NAD⁺-dependent deacetylation mechanism
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TN_cdi_fao_agris_US201600138193
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600138193
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1303628110
