Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as...
Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice
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Author / Creator
Murphy, Andrew J. , Macdonald, Lynn E. , Stevens, Sean , Karow, Margaret , Dore, Anthony T. , Pobursky, Kevin , Huang, Tammy T. , Poueymirou, William T. , Esau, Lakeisha , Meola, Melissa , Mikulka, Warren , Krueger, Pamela , Fairhurst, Jeanette , Valenzuela, David M. , Papadopoulos, Nicholas and Yancopoulos, George D.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Mice genetically engineered to be humanized for their Ig genes allow for human antibody responses within a mouse background (HumAb mice), providing a valuable platform for the generation of fully human therapeutic antibodies. Unfortunately, existing HumAb mice do not have fully functional immune systems, perhaps because of the manner in which their...
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Full title
Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice
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Record Identifier
TN_cdi_fao_agris_US201600143451
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600143451
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1324022111
