Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology
Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology
About this item
Full title
Author / Creator
Schilling, Stephan , Zeitschel, Ulrike , Hoffmann, Torsten , Heiser, Ulrich , Francke, Mike , Kehlen, Astrid , Holzer, Max , Hutter-Paier, Birgit , Prokesch, Manuela , Windisch, Manfred , Jagla, Wolfgang , Schlenzig, Dagmar , Lindner, Christiane , Rudolph, Thomas , Reuter, Gunter , Cynis, Holger , Montag, Dirk , Demuth, Hans-Ulrich and Rossner, Steffen
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
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Scope and Contents
Contents
Some Aβ peptides contain pyroglutamate modifications that affect the aggregation properties of these peptides. The authors find that the enzyme glutaminyl cyclase is responsible for this pyroglutamate modification. When they inhibit the enzyme in Alzheimer's model mice, fewer plaques form in the brain, and some measures of learning and memory are i...
Alternative Titles
Full title
Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology
Authors, Artists and Contributors
Author / Creator
Zeitschel, Ulrike
Hoffmann, Torsten
Heiser, Ulrich
Francke, Mike
Kehlen, Astrid
Holzer, Max
Hutter-Paier, Birgit
Prokesch, Manuela
Windisch, Manfred
Jagla, Wolfgang
Schlenzig, Dagmar
Lindner, Christiane
Rudolph, Thomas
Reuter, Gunter
Cynis, Holger
Montag, Dirk
Demuth, Hans-Ulrich
Rossner, Steffen
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracgeneralonefile_A194904744
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracgeneralonefile_A194904744
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.1872
