RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF
About this item
Full title
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF
Author / Creator
Publisher
Nature Publishing Group
Journal title
Nature, 2011, Vol.480 (7377), p.387
Language
English
Formats
Publication information
Publisher
Nature Publishing Group
Subjects
More information
Scope and Contents
Contents
Although clinical trials have shown that RAF inhibitors prolong the survival of patients with BRAF-mutant melanoma, resistance inevitably develops; resistance is shown here to be frequently mediated by the expression of splicing variants of mutant BRAF.
Alternative Titles
Full title
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A626152078
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A626152078
Other Identifiers
ISSN
0028-0836
DOI
10.1038/nature10662
How to access this item
Log in as a Library member
