A single droplet digital PCR for ESR1 activating mutations detection in plasma
A single droplet digital PCR for ESR1 activating mutations detection in plasma
About this item
Full title
Author / Creator
Jeannot, Emmanuelle , Darrigues, Lauren , Michel, Marc , Stern, Marc-Henri , Pierga, Jean-Yves , Rampanou, Aurore , Melaabi, Samia , Benoist, Camille , Bièche, Ivan , Vincent-Salomon, Anne , El Ayachy, Radouane , Noret, Aurélien , Epaillard, Nicolas , Cabel, Luc , Bidard, François-Clément and Proudhon, Charlotte
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Activating mutations in the estrogen receptor 1 (
ESR1
) gene confer resistance to aromatase inhibitors (AI), and may be targeted by selective estrogen receptor downregulators. We designed a multiplex droplet digital PCR (ddPCR), which combines a drop-off assay, targeting the clustered hotspot mutations found in exon 8, with an unconventional...
Alternative Titles
Full title
A single droplet digital PCR for ESR1 activating mutations detection in plasma
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_03228138v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03228138v1
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-020-1174-y
