Osteoblast Expression of an Engineered${\rm G}_{{\rm s}}\text{-Coupled}$Receptor Dramatically Increa...
Osteoblast Expression of an Engineered${\rm G}_{{\rm s}}\text{-Coupled}$Receptor Dramatically Increases Bone Mass
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National Academy of Sciences
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English
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National Academy of Sciences
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Osteoblasts are essential for maintaining bone mass, avoiding osteoporosis, and repairing injured bone. Activation of osteoblast G protein-coupled receptors (GPCRs), such as the parathyroid hormone receptor, can increase bone mass; however, the anabolic mechanisms are poorly understood. Here we use "Rs1," an engineered GPCR with constitutive ${\rm...
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Osteoblast Expression of an Engineered${\rm G}_{{\rm s}}\text{-Coupled}$Receptor Dramatically Increases Bone Mass
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TN_cdi_jstor_primary_25451254
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25451254
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ISSN
0027-8424
DOI
10.1073/pnas.0707457105
