Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
About this item
Full title
Author / Creator
Mavrakis, Konstantinos J. , McDonald, E. Robert , Schlabach, Michael R. , Billy, Eric , Hoffman, Gregory R. , deWeck, Antoine , Ruddy, David A. , Venkatesan, Kavitha , Yu, Jianjun , McAllister, Gregg , Stump, Mark , deBeaumont, Rosalie , Ho, Samuel , Yue, Yingzi , Liu, Yue , Yan-Neale, Yan , Yang, Guizhi , Lin, Fallon , Yin, Hong , Gao, Hui , Kipp, D. Randal , Zhao, Songping , McNamara, Joshua T. , Sprague, Elizabeth R. , Zheng, Bing , Lin, Ying , Cho, Young Shin , Gu, Justin , Crawford, Kenneth , Ciccone, David , Vitari, Alberto C. , Lai, Albert , Capka, Vladimir , Hurov, Kristen , Porter, Jeffery A. , Tallarico, John , Mickanin, Craig , Lees, Emma , Pagliarini, Raymond , Keen, Nicholas , Schmelzle, Tobias , Hofmann, Francesco , Stegmeier, Frank , Sellers, William R. and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway. The MTAP gene is frequently deleted in human cancers because of its chromosomal proximity to the tumor suppressor gene CDKN2A. By interrogating data from a large-scale short hairpin RNA–mediated screen across 390 cancer cell line models, we found that the...
Alternative Titles
Full title
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Authors, Artists and Contributors
Author / Creator
McDonald, E. Robert
Schlabach, Michael R.
Billy, Eric
Hoffman, Gregory R.
deWeck, Antoine
Ruddy, David A.
Venkatesan, Kavitha
Yu, Jianjun
McAllister, Gregg
Stump, Mark
deBeaumont, Rosalie
Ho, Samuel
Yue, Yingzi
Liu, Yue
Yan-Neale, Yan
Yang, Guizhi
Lin, Fallon
Yin, Hong
Gao, Hui
Kipp, D. Randal
Zhao, Songping
McNamara, Joshua T.
Sprague, Elizabeth R.
Zheng, Bing
Lin, Ying
Cho, Young Shin
Gu, Justin
Crawford, Kenneth
Ciccone, David
Vitari, Alberto C.
Lai, Albert
Capka, Vladimir
Hurov, Kristen
Porter, Jeffery A.
Tallarico, John
Mickanin, Craig
Lees, Emma
Pagliarini, Raymond
Keen, Nicholas
Schmelzle, Tobias
Hofmann, Francesco
Stegmeier, Frank
Sellers, William R.
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_1404991
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1404991
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aad5944
