Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomera...
Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Telomerase activity is readily detectable in extracts from human hematopoietic stem and progenitor cells, but appears unable to maintain telomere length with proliferation in vitro and with age in vivo. We performed a detailed study of the telomere length by flow FISH analysis in leukocytes from 835 healthy individuals and 60 individuals with reduc...
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Full title
Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes
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TN_cdi_plos_journals_1313631371
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313631371
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1002696
