Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic D...
Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction
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Author / Creator
Watterson, D Martin , Grum-Tokars, Valerie L , Roy, Saktimayee M , Schavocky, James P , Bradaric, Brinda Desai , Bachstetter, Adam D , Xing, Bin , Dimayuga, Edgardo , Saeed, Faisal , Zhang, Hong , Staniszewski, Agnieszka , Pelletier, Jeffrey C , Minasov, George , Anderson, Wayne F , Arancio, Ottavio and Van Eldik, Linda J
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Serine-threonine protein kinases are critical to CNS function, yet there is a dearth of highly selective, CNS-active kinase inhibitors for in vivo investigations. Further, prevailing assumptions raise concerns about whether single kinase inhibitors can show in vivo efficacy for CNS pathologies, and debates over viable approaches to the development...
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Full title
Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction
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TN_cdi_plos_journals_1371831037
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1371831037
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0066226
