Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxi...
Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Autophagy, a lysosomal self-degradation and recycling pathway, plays dual roles in tumorigenesis. Autophagy deficiency predisposes to cancer, at least in part, through accumulation of the selective autophagy cargo p62, leading to activation of antioxidant responses and tumor formation. While cell growth and autophagy are inversely regulated in most...
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Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster
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TN_cdi_plos_journals_1433014551
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1433014551
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1003664
