Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis
Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Flux balance analysis (FBA) is an increasingly useful approach for modeling the behavior of metabolic systems. However, standard FBA modeling of genetic knockouts cannot predict drug combination synergies observed between serial metabolic targets, even though such synergies give rise to some of the most widely used antibiotic treatments. Here we ex...
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Full title
Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis
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TN_cdi_plos_journals_1761076151
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1761076151
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0147651
