Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene E...
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects. Using RNA-seq, we evaluated targeted and neighboring gene expression in tissues from 44 homozygous mutants compared with C57BL/6N control mice....
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Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression
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TN_cdi_plos_journals_1773769552
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1773769552
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1005691
