Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogeni...
Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Mitochondrial import of pyruvate by the mitochondrial pyruvate carrier (MPC) is a central step which links cytosolic and mitochondrial intermediary metabolism. To investigate the role of the MPC in mammalian physiology and development, we generated a mouse strain with complete loss of MPC1 expression. This resulted in embryonic lethality at around...
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Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet
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TN_cdi_plos_journals_1797508856
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1797508856
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1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006056
