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Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate c...

Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate c...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1895360316

Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate cells activation

About this item

Full title

Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate cells activation

Publisher

United States: Public Library of Science

Journal title

PloS one, 2017-05, Vol.12 (5), p.e0176173-e0176173

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

During liver injury, hepatic stellate cells (HSCs) can undergo activation and transform into alpha-smooth muscle actin (αSMA)-expressing contractile myofibroblast-like cells, leading to deposition of excessive scar matrix. We have recently demonstrated that depletion of adenosine deaminase acting on double-stranded RNA (ADAR1) from mouse hepatocyte...

Alternative Titles

Full title

Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate cells activation

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1895360316

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1895360316

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0176173

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