A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers
A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Most B cell cancers overexpress the enzyme activation-induced deaminase at high levels and this enzyme converts cytosines in DNA to uracil. The constitutive expression of this enzyme in these cells greatly increases the uracil content of their genomes. We show here that these genomes also contain high levels of abasic sites presumably created durin...
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Full title
A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers
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TN_cdi_plos_journals_1940544070
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1940544070
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0185010
