Modeling Insertional Mutagenesis Using Gene Length and Expression in Murine Embryonic Stem Cells
Modeling Insertional Mutagenesis Using Gene Length and Expression in Murine Embryonic Stem Cells
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United States: Public Library of Science
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English
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United States: Public Library of Science
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High-throughput mutagenesis of the mammalian genome is a powerful means to facilitate analysis of gene function. Gene trapping in embryonic stem cells (ESCs) is the most widely used form of insertional mutagenesis in mammals. However, the rules governing its efficiency are not fully understood, and the effects of vector design on the likelihood of...
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Modeling Insertional Mutagenesis Using Gene Length and Expression in Murine Embryonic Stem Cells
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TN_cdi_plos_journals_1950182990
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1950182990
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0000617
