Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling
Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Ferrochelatase (FECH) is an enzyme necessary for heme synthesis, which is essential for maintaining normal functions of endothelial nitric oxide synthase (eNOS) and soluble guanylyl cyclase (sGC). We tested the hypothesis that inhibition of vascular FECH to attenuate heme synthesis downregulates eNOS and sGC expression, resulting in impaired NO/cGM...
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Full title
Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling
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TN_cdi_plos_journals_2067606908
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2067606908
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0200307
