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Ferrochelatase is a therapeutic target for ocular neovascularization
Author / Creator:Basavarajappa, Halesha D ; Sulaiman, Rania S ; Qi, Xiaoping ; Shetty, Trupti ; Sheik Pran Babu, Sardar ; Sishtla, Kamakshi L ; Lee, Bit ; Quigley, Judith ; Alkhairy, Sameerah ; Briggs, Christian M ; Gupta, Kamna ; Tang, Buyun ; Shadmand, Mehdi ; Grant, Maria B ; Boulton, Michael E ; Seo, Seung‐Yong ; Corson, Timothy W
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2017-06, Vol.9 (6), p.786-801
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Substrate interactions with human ferrochelatase
Author / Creator:Medlock, Amy ; Swartz, Larkin ; Dailey, Tamara A ; Dailey, Harry A ; Lanzilotta, William N
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (6), p.1789-1793
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Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy
Author / Creator:Teng, L ; Nakada, M ; Zhao, S-G ; Endo, Y ; Furuyama, N ; Nambu, E ; Pyko, I V ; Hayashi, Y ; Hamada, J-I
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2011-03, Vol.104 (5), p.798-807
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Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations
Author / Creator:Guo, Mingshan ; Lin, Yuhong ; Obi, Chibuike David ; Zhao, Peng ; Dailey, Harry A ; Medlock, Amy E ; Shen, Yong
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-06, Vol.25 (12), p.6360
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Overexpression of chloroplast-targeted ferrochelatase 1 results in a genomes uncoupled chloroplast-to-nucleus retrograde signalling phenotype
Author / Creator:Page, Mike T ; Garcia-Becerra, Tania ; Smith, Alison G ; Terry, Matthew J
Publisher:England: The Royal Society
Journal title:Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2020-06, Vol.375 (1801), p.20190401-20190401
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Salt stress-induced FERROCHELATASE 1 improves resistance to salt stress by limiting sodium accumulation in Arabidopsis thaliana
Author / Creator:Zhao, Wen Ting ; Feng, Sheng Jun ; Li, Hua ; Faust, Franziska ; Kleine, Tatjana ; Li, Long Na ; Yang, Zhi Min
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-11, Vol.7 (1), p.14737-16, Article 14737
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The core autophagy machinery is not required for chloroplast singlet oxygen-mediated cell death in the Arabidopsis thaliana plastid ferrochelatase two mutant
Author / Creator:Lemke, Matthew D ; Fisher, Karen E ; Kozlowska, Marta A ; Tano, David W ; Woodson, Jesse D
Publisher:London: BioMed Central Ltd
Journal title:BMC plant biology, 2021-07, Vol.21 (1), p.342-342, Article 342
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Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling
Author / Creator:Zhang, Bin ; Alruwaili, Norah ; Kandhi, Sharath ; Deng, Wensheng ; Huang, An ; Wolin, Michael S ; Sun, Dong
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-07, Vol.13 (7), p.e0200307-e0200307
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Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes
Author / Creator:Wu, Bo ; Novelli, Jacopo ; Jiang, Daojun ; Dailey, Harry A. ; Landmann, Frédéric ; Ford, Louise ; Taylor, Mark J. ; Carlow, Clotilde K. S. ; Kumar, Sanjay ; Foster, Jeremy M. ; Slatko, Barton E.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (19), p.7748-7753
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Proteomic Analysis of Ferrochelatase Interactome in Erythroid and Non-Erythroid Cells
Author / Creator:Obi, Chibuike David ; Dailey, Harry A ; Jami-Alahmadi, Yasaman ; Wohlschlegel, James A ; Medlock, Amy E
Publisher:Switzerland: MDPI AG
Journal title:Life (Basel, Switzerland), 2023-02, Vol.13 (2), p.577
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Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice
Author / Creator:Barman-Aksözen, Jasmin ; C Wiek, Paulina ; Bansode, Vijay B ; Koentgen, Frank ; Trüb, Judith ; Pelczar, Pawel ; Cinelli, Paolo ; Schneider-Yin, Xiaoye ; Schümperli, Daniel ; Minder, Elisabeth I
Publisher:England: The Company of Biologists Ltd
Journal title:Disease models & mechanisms, 2017-03, Vol.10 (3), p.225-233
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Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by ferrochelatase inhibitor in urothelial carcinoma
Author / Creator:Inoue, Keiji ; Fukuhara, Hideo ; Kurabayashi, Atsushi ; Furihata, Mutsuo ; Tsuda, Masayuki ; Nagakawa, Keisuke ; Fujita, Hirofumi ; Utsumi, Kozo ; Shuin, Taro
Publisher:England: John Wiley and Sons Inc
Journal title:Cancer science, 2013-06, Vol.104 (6), p.765-772
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role of coproporphyrinogen III oxidase and ferrochelatase genes in heme biosynthesis and regulation in Aspergillus niger
Author / Creator:Franken, Angelique C. W ; Werner, Ernst R ; Haas, Hubertus ; Lokman, B. Christien ; van den Hondel, Cees A. M. J. J ; Ram, Arthur F. J ; de Weert, Sandra ; Punt, Peter J
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Applied microbiology and biotechnology, 2013-11, Vol.97 (22), p.9773-9785
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Griseofulvin impairs intraerythrocytic growth of Plasmodium falciparum through ferrochelatase inhibition but lacks activity in an experimental human infection study
Author / Creator:Smith, Clare M. ; Jerkovic, Ante ; Truong, Thy Thuc ; Foote, Simon J. ; McCarthy, James S. ; McMorran, Brendan J.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-02, Vol.7 (1), p.41975-41975, Article 41975
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Mechanism of the Affinity-Enhancing Effect of Isatin on Human Ferrochelatase and Adrenodoxin Reductase Complex Formation: Implication for Protein Interactome Regulation
Author / Creator:Ershov, Pavel V ; Veselovsky, Alexander V ; Mezentsev, Yuri V ; Yablokov, Evgeniy O ; Kaluzhskiy, Leonid A ; Tumilovich, Anastasiya M ; Kavaleuski, Anton A ; Gilep, Andrei A ; Moskovkina, Taisiya V ; Medvedev, Alexei E ; Ivanov, Alexis S
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-10, Vol.21 (20), p.7605
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The 2.0 Å structure of human ferrochelatase, the terminal enzyme of heme biosynthesis
Author / Creator:Wu, Chia-Kuei ; Dailey, Harry A. ; Rose, John P. ; Burden, Amy ; Sellers, Vera M. ; Wang, Bi-Cheng
Publisher:New York: Nature Publishing Group US
Journal title:Nature Structural Biology, 2001-02, Vol.8 (2), p.156-160
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Loss-of-function ferrochelatase and gain-of-function erythroid-specific 5-aminolevulinate synthase mutations causing erythropoietic protoporphyria and x-linked protoporphyria in North American patient...
Author / Creator:Balwani, Manisha ; Doheny, Dana ; Bishop, David F ; Nazarenko, Irina ; Yasuda, Makiko ; Dailey, Harry A ; Anderson, Karl E ; Bissell, D Montgomery ; Bloomer, Joseph ; Bonkovsky, Herbert L ; Phillips, John D ; Liu, Lawrence ; Desnick, Robert J
Publisher:England: BioMed Central
Journal title:Molecular medicine (Cambridge, Mass.), 2013-01, Vol.19 (1), p.26-29
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Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters
Author / Creator:Dailey, H A ; Dailey, T A ; Wu, C K ; Medlock, A E ; Wang, K F ; Rose, J P ; Wang, B C
Publisher:Switzerland: Springer Nature B.V
Journal title:Cellular and molecular life sciences : CMLS, 2000-12, Vol.57 (13-14), p.1909-1926
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Identification of a bacteria-like ferrochelatase in Strongyloides venezuelensis, an animal parasitic nematode
Author / Creator:Nagayasu, Eiji ; Ishikawa, Sohta A ; Taketani, Shigeru ; Chakraborty, Gunimala ; Yoshida, Ayako ; Inagaki, Yuji ; Maruyama, Haruhiko
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-03, Vol.8 (3), p.e58458-e58458
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Functional Assignments for the Carboxyl-Terminal Domains of the Ferrochelatase from Synechocystis PCC 6803: The CAB Domain Plays a Regulatory Role, and Region II Is Essential for Catalysis
Author / Creator:Sobotka, Roman ; Tichy, Martin ; Wilde, Annegret ; Hunter, C. Neil
Publisher:United States: American Society of Plant Biologists
Journal title:Plant physiology (Bethesda), 2011-04, Vol.155 (4), p.1735-1747
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Ferrochelatase is a therapeutic target for ocular neovascularization

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Substrate interactions with human ferrochelatase

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Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy

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Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations

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Overexpression of chloroplast-targeted ferrochelatase 1 results in a genomes uncoupled chloroplast-to-nucleus retrograde signalling phenotype

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Salt stress-induced FERROCHELATASE 1 improves resistance to salt stress by limiting sodium accumulation in Arabidopsis thaliana

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The core autophagy machinery is not required for chloroplast singlet oxygen-mediated cell death in the Arabidopsis thaliana plastid ferrochelatase two mutant

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Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling

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Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes

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Proteomic Analysis of Ferrochelatase Interactome in Erythroid and Non-Erythroid Cells

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Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice

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Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by ferrochelatase inhibitor in urothelial carcinoma

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role of coproporphyrinogen III oxidase and ferrochelatase genes in heme biosynthesis and regulation in Aspergillus niger

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Griseofulvin impairs intraerythrocytic growth of Plasmodium falciparum through ferrochelatase inhibition but lacks activity in an experimental human infection study

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Mechanism of the Affinity-Enhancing Effect of Isatin on Human Ferrochelatase and Adrenodoxin Reductase Complex Formation: Implication for Protein Interactome Regulation

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The 2.0 Å structure of human ferrochelatase, the terminal enzyme of heme biosynthesis

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Loss-of-function ferrochelatase and gain-of-function erythroid-specific 5-aminolevulinate synthase mutations causing erythropoietic protoporphyria and x-linked protoporphyria in North American patient...

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Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters

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Identification of a bacteria-like ferrochelatase in Strongyloides venezuelensis, an animal parasitic nematode

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Functional Assignments for the Carboxyl-Terminal Domains of the Ferrochelatase from Synechocystis PCC 6803: The CAB Domain Plays a Regulatory Role, and Region II Is Essential for Catalysis

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