Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strai...
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Mutations in Cu/Zn superoxide dismutase 1 (SOD1) associated with familial amyotrophic lateral sclerosis cause the protein to aggregate via a prion-like process in which soluble molecules are recruited to aggregates by conformational templating. These misfolded SOD1 proteins can propagate aggregation-inducing conformations across cellular membranes....
Alternative Titles
Full title
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2348791833
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2348791833
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0227655
