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ArticlesPeer ReviewedFull Text
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
Author / Creator:Sacino, Amanda N. ; Brooks, Mieu ; Thomas, Michael A. ; McKinney, Alex B. ; Lee, Sooyeon ; Regenhardt, Robert W. ; McGarvey, Nicholas H. ; Ayers, Jacob I. ; Notterpek, Lucia ; Borchelt, David R. ; Golde, Todd E. ; Giasson, Benoit I.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10732-10737
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ArticlesPeer ReviewedFull Text
Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways
Author / Creator:Ayers, Jacob I. ; Fromholt, Susan E. ; O’Neal, Veronica M. ; Diamond, Jeffrey H. ; Borchelt, David R.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2016-01, Vol.131 (1), p.103-114
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ArticlesPeer ReviewedFull Text
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection
Author / Creator:Crown, Anthony ; McAlary, Luke ; Fagerli, Eric ; Brown, Hilda ; Yerbury, Justin J. ; Galaleldeen, Ahmad ; Cashman, Neil R. ; Borchelt, David R. ; Ayers, Jacob I.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2020-01, Vol.15 (1), p.e0227655
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ArticlesPeer ReviewedFull Text
Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS
Author / Creator:Ayers, Jacob I. ; Diamond, Jeffrey ; Sari, Adriana ; Fromholt, Susan ; Galaleldeen, Ahmad ; Ostrow, Lyle W. ; Glass, Jonathan D. ; Hart, P. John ; Borchelt, David R.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2016-12, Vol.132 (6), p.827-840
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ArticlesPeer ReviewedFull Text
Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice
Author / Creator:Ayers, Jacob I. ; Xu, Guilian ; Lu, Qing ; Dillon, Kristy ; Fromholt, Susan ; Borchelt, David R.
Publisher:Basel: MDPI AG
Journal title:Viruses, 2023-08, Vol.15 (9), p.1819
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ArticlesPeer ReviewedFull Text
The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease
Author / Creator:Ayers, Jacob I. ; Schutt, Charles R. ; Shikiya, Ronald A. ; Aguzzi, Adriano ; Kincaid, Anthony E. ; Bartz, Jason C.
Publisher:San Francisco: Public Library of Science
Journal title:PLoS pathogens, 2011-03, Vol.7 (3), p.e1001317
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ArticlesPeer ReviewedFull Text
The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease
Author / Creator:Ayers, Jacob I ; Schutt, Charles R ; Shikiya, Ronald A ; Aguzzi, Adriano ; Kincaid, Anthony E ; Bartz, Jason C
Publisher:United States: Public Library of Science (PLoS)
Journal title:PLoS pathogens, 2011-03, Vol.7 (3), p.e1001317-e1001317
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ArticlesPeer ReviewedFull Text
Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models
Author / Creator:Crosby, Keith ; Crown, Anthony M. ; Roberts, Brittany L. ; Brown, Hilda ; Ayers, Jacob I. ; Borchelt, David R.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-11, Vol.13 (11), p.e0206751-e0206751
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Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence
Author / Creator:Ayers, Jacob I. ; Xu, Guilian ; Dillon, Kristy ; Lu, Qing ; Chen, Zhijuan ; Beckman, John ; Moreno-Romero, Alma K. ; Zamora, Diana L. ; Galaleldeen, Ahmad ; Borchelt, David R.
Publisher:England: BioMed Central Ltd
Journal title:Acta neuropathologica communications, 2021-05, Vol.9 (1), p.92-92, Article 92
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Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis
Author / Creator:Crown, Anthony M ; Roberts, Brittany L ; Crosby, Keith ; Brown, Hilda ; Ayers, Jacob I ; Hart, P John ; Borchelt, David R
Publisher:Oxford: Oxford University Press
Journal title:G3 : genes - genomes - genetics, 2019-03, Vol.9 (3), p.719-728
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ArticlesPeer ReviewedFull Text
Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases
Author / Creator:Ayers, Jacob I ; Xu, Guilian ; Pletnikova, Olga ; Troncoso, Juan C ; Hart, P John ; Borchelt, David R
Publisher:England: BioMed Central Ltd
Journal title:Acta neuropathologica communications, 2014-05, Vol.2 (1), p.55-55, Article 55
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ArticlesPeer ReviewedFull Text
Phenotypic diversity in ALS and the role of poly-conformational protein misfolding
Author / Creator:Ayers, Jacob I. ; Borchelt, David R.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2021-07, Vol.142 (1), p.41-55
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Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy
Author / Creator:Ayers, Jacob I. ; Lee, Joanne ; Monteiro, Octovia ; Woerman, Amanda L. ; Lazar, Ann A. ; Condello, Carlo ; Paras, Nick A. ; Prusiner, Stanley B.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (6), p.1-9
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ArticlesPeer ReviewedFull Text
Experimental transmissibility of mutant SOD1 motor neuron disease
Author / Creator:Ayers, Jacob I. ; Fromholt, Susan ; Koch, Morgan ; DeBosier, Adam ; McMahon, Ben ; Xu, Guilian ; Borchelt, David R.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2014-12, Vol.128 (6), p.791-803
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ArticlesPeer ReviewedFull Text
Prion protein — mediator of toxicity in multiple proteinopathies
Author / Creator:Ayers, Jacob I. ; Prusiner, Stanley B.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Neurology, 2020-04, Vol.16 (4), p.187-188
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Widespread and Efficient Transduction of Spinal Cord and Brain Following Neonatal AAV Injection and Potential Disease Modifying Effect in ALS Mice
Author / Creator:Ayers, Jacob I ; Fromholt, Susan ; Sinyavskaya, Olga ; Siemienski, Zoe ; Rosario, Awilda M ; Li, Andrew ; Crosby, Keith W ; Cruz, Pedro E ; DiNunno, Nadia M ; Janus, Christopher ; Ceballos-Diaz, Carolina ; Borchelt, David R ; Golde, Todd E ; Chakrabarty, Paramita ; Levites, Yona
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2015-01, Vol.23 (1), p.53-62
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Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology
Author / Creator:Sacino, Amanda N. ; Ayers, Jacob I. ; Brooks, Mieu M. T. ; Chakrabarty, Paramita ; Hudson, Vincent J. ; Howard, Jasie K. ; Golde, Todd E. ; Giasson, Benoit I. ; Borchelt, David R.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2016-01, Vol.131 (1), p.151-154
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Newsletter articlesFull Text
Crest Middle School honor roll
Publisher:Washington: Tribune Content Agency LLC
Journal title:McClatchy - Tribune Business News, 2009
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ArticlesFull Text
Loss of charge at solvent exposed Lys residues does not induce the aggregation of superoxide dismutase 1
Author / Creator:Crosby, Keith ; Crown, Anthony M ; Roberts, Brittany L ; Brown, Hilda ; Ayers, Jacob I ; Borchelt, David
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2018-04
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Non-prion-type transmission in A53T [alpha]-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust [alpha]-synuclein pathology
Author / Creator:Sacino, Amanda N ; Ayers, Jacob I ; Brooks, Mieu M; T ; Chakrabarty, Paramita ; Hudson, Vincent J ; Howard, Jasie K ; Golde, Todd E ; Giasson, Benoit I ; Borchelt, David R
Publisher:Heidelberg: Springer Nature B.V
Journal title:Acta neuropathologica, 2016-01, Vol.131 (1), p.151
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Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

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Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

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Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

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Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

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Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

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The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

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The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease

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Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

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Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

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Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

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Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

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Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

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Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy

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Experimental transmissibility of mutant SOD1 motor neuron disease

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Prion protein — mediator of toxicity in multiple proteinopathies

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Widespread and Efficient Transduction of Spinal Cord and Brain Following Neonatal AAV Injection and Potential Disease Modifying Effect in ALS Mice

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Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology

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Crest Middle School honor roll

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Loss of charge at solvent exposed Lys residues does not induce the aggregation of superoxide dismutase 1

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Non-prion-type transmission in A53T [alpha]-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust [alpha]-synuclein pathology

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