Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resona...
Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resonance for identification of small-molecule Argonaute 2 inhibitors
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Publisher
San Francisco: Public Library of Science
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Language
English
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Publisher
San Francisco: Public Library of Science
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Contents
Argonaute (AGO) proteins are the key component of the RNA interference machinery that suppresses gene expression by forming an RNA-induced silencing complex (RISC) with microRNAs (miRNAs). Each miRNA is involved in various cellular processes, such as development, differentiation, tumorigenesis, and viral infection. Thus, molecules that regulate miR...
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Full title
Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resonance for identification of small-molecule Argonaute 2 inhibitors
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TN_cdi_plos_journals_2429431381
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2429431381
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0236710
