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Restricting extracellular Ca2+ on gefitinib-resistant non-small cell lung cancer cells reverses alte...

Restricting extracellular Ca2+ on gefitinib-resistant non-small cell lung cancer cells reverses alte...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2437106640

Restricting extracellular Ca2+ on gefitinib-resistant non-small cell lung cancer cells reverses altered epidermal growth factor-mediated Ca2+ response, which consequently enhances gefitinib sensitivity

About this item

Full title

Restricting extracellular Ca2+ on gefitinib-resistant non-small cell lung cancer cells reverses altered epidermal growth factor-mediated Ca2+ response, which consequently enhances gefitinib sensitivity

Publisher

San Francisco: Public Library of Science

Journal title

PloS one, 2020-08, Vol.15 (8), p.e0238155-e0238155

Language

English

Formats

Publication information

Publisher

San Francisco: Public Library of Science

More information

Scope and Contents

Contents

Non-small cell lung cancer (NSCLC), one of the leading causes of cancer-related death, has a low 5-year survival rate owing to the inevitable acquired resistance toward antitumor drugs, platinum-based chemotherapy, and targeted therapy. Epidermal growth factor (EGF)-EGF receptor (EGFR) signaling activates downstream events leading to phospholipase...

Alternative Titles

Full title

Restricting extracellular Ca2+ on gefitinib-resistant non-small cell lung cancer cells reverses altered epidermal growth factor-mediated Ca2+ response, which consequently enhances gefitinib sensitivity

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2437106640

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2437106640

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0238155

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