Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in...
Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Ribosomal DNA (rDNA) genes encode the structural RNAs of the ribosome and are present in hundreds of copies in mammalian genomes. Age-linked DNA hypermethylation throughout the rDNA constitutes a robust "methylation clock" that accurately reports age, yet the consequences of hypermethylation on rDNA function are unknown. We confirmed that pervasive...
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Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells
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TN_cdi_plos_journals_3143784506
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3143784506
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0310626
