Allosteric and hyperekplexic mutant phenotypes investigated on an α₁ glycine receptor transmembrane...
Allosteric and hyperekplexic mutant phenotypes investigated on an α₁ glycine receptor transmembrane structure
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Significance Pentameric ligand-gated ion channels (pLGICs) mediate neuronal communication in the central nervous system. Upon the neurotransmitter binding, these receptors undergo a rapid conformational change to open an integral ion channel. Mutations impairing the function of pLGICs are known to cause hyperekplexic, myasthenic, and epileptic synd...
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Full title
Allosteric and hyperekplexic mutant phenotypes investigated on an α₁ glycine receptor transmembrane structure
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Record Identifier
TN_cdi_pnas_primary_112_9_2865
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_112_9_2865
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1417864112
