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ArticlesPeer ReviewedFull Text
The desensitization pathway of GABAA receptors, one subunit at a time
Author / Creator:Gielen, Marc ; Barilone, Nathalie ; Corringer, Pierre-Jean
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-10, Vol.11 (1), p.5369-5369, Article 5369
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Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry
Author / Creator:Peverini, Laurie ; Shi, Sophie ; Medjebeur, Karima ; Corringer, Pierre-Jean
Publisher:Cambridge: eLife Sciences Publications Ltd
Journal title:eLife, 2024-06, Vol.12
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Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
Author / Creator:Sauguet, Ludovic ; Poitevin, Frédéric ; Murail, Samuel ; Van Renterghem, Catherine ; Moraga-Cid, Gustavo ; Malherbe, Laurie ; Thompson, Andrew W ; Koehl, Patrice ; Corringer, Pierre-Jean ; Baaden, Marc ; Delarue, Marc
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2013-03, Vol.32 (5), p.728-741
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Short‐chain mono‐carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand‐gated ion channel, and impact of a pre‐β5 strand (Loop Ω) double mutation on crotonate, n...
Author / Creator:Van Renterghem, Catherine ; Nemecz, Ákos ; Medjebeur, Karima ; Corringer, Pierre‐Jean
Publisher:United States: John Wiley & Sons, Inc
Journal title:Physiological reports, 2024-02, Vol.12 (3), p.e15916-n/a
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Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation
Author / Creator:Lefebvre, Solène N ; Taly, Antoine ; Menny, Anaïs ; Medjebeur, Karima ; Corringer, Pierre-Jean
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2021-09, Vol.10
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Identification of a pre-active conformation of a pentameric channel receptor
Author / Creator:Menny, Anaïs ; Lefebvre, Solène N ; Schmidpeter, Philipp Am ; Drège, Emmanuelle ; Fourati, Zaineb ; Delarue, Marc ; Edelstein, Stuart J ; Nimigean, Crina M ; Joseph, Delphine ; Corringer, Pierre-Jean
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2017-03, Vol.6
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Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
Author / Creator:Taly, Antoine ; Corringer, Pierre-Jean ; Guedin, Denis ; Lestage, Pierre ; Changeux, Jean-Pierre
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2009-09, Vol.8 (9), p.733-750
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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
Author / Creator:Bocquet, Nicolas ; Nury, Hugues ; Baaden, Marc ; Le Poupon, Chantal ; Changeux, Jean-Pierre ; Delarue, Marc ; Corringer, Pierre-Jean
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2009-01, Vol.457 (7225), p.111-114
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Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
Author / Creator:Sauguet, Ludovic ; Shahsavar, Azadeh ; Poitevin, Frédéric ; Huon, Christèle ; Menny, Anaïs ; Nemecz, Àkos ; Haouz, Ahmed ; Changeux, Jean-Pierre ; Corringer, Pierre-Jean ; Delarue, Marc
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-01, Vol.111 (3), p.966-971
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A millisecond coarse-grained simulation approach to decipher allosteric cannabinoid binding at the glycine receptor α1
Author / Creator:Bartocci, Alessio ; Grazzi, Andrea ; Awad, Nour ; Corringer, Pierre-Jean ; Souza, Paulo C. T. ; Cecchini, Marco
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-10, Vol.15 (1), p.9040-13, Article 9040
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Structural titration of receptor ion channel GLIC gating by HS-AFM
Author / Creator:Ruan, Yi ; Kao, Kevin ; Lefebvre, Solène ; Marchesi, Arin ; Corringer, Pierre-Jean ; Hite, Richard K. ; Scheuring, Simon
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (41), p.10333-10338
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Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors
Author / Creator:Prevost, Marie S. ; Bouchenaki, Hichem ; Barilone, Nathalie ; Gielen, Marc ; Corringer, Pierre-Jean
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2021-02, Vol.78 (3), p.1051-1064
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ArticlesPeer ReviewedFull Text
Illumination of a progressive allosteric mechanism mediating the glycine receptor activation
Author / Creator:Shi, Sophie ; Lefebvre, Solène N. ; Peverini, Laurie ; Cerdan, Adrien H. ; Milán Rodríguez, Paula ; Gielen, Marc ; Changeux, Jean-Pierre ; Cecchini, Marco ; Corringer, Pierre-Jean
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-02, Vol.14 (1), p.795-795, Article 795
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An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies
Author / Creator:Prevost, Marie S. ; Barilone, Nathalie ; Dejean de la Bâtie, Gabrielle ; Pons, Stéphanie ; Ayme, Gabriel ; England, Patrick ; Gielen, Marc ; Bontems, François ; Pehau-Arnaudet, Gérard ; Maskos, Uwe ; Lafaye, Pierre ; Corringer, Pierre-Jean
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-09, Vol.14 (1), p.5964-5964, Article 5964
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ArticlesPeer ReviewedFull Text
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue
Author / Creator:Nury, Hugues ; Poitevin, Frédéric ; Van Renterghem, Catherine ; Changeux, Jean-Pierre ; Corringer, Pierre-Jean ; Delarue, Marc ; Baaden, Marc
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (14), p.6275-6280
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Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel
Author / Creator:Nemecz, Ákos ; Hu, Haidai ; Fourati, Zaineb ; Van Renterghem, Catherine ; Delarue, Marc ; Corringer, Pierre-Jean
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2017-12, Vol.15 (12), p.e2004470-e2004470
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A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family
Author / Creator:BOCQUET, Nicolas ; PRADO DE CARVALHO, Lia ; CARTAUD, Jean ; NEYTON, Jacques ; LE POUPON, Chantal ; TALY, Antoine ; GRUTTER, Thomas ; CHANGEUX, Jean-Pierre ; CORRINGER, Pierre-Jean
Publisher:London: Nature Publishing
Journal title:Nature, 2007-01, Vol.445 (7123), p.116-119
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Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines
Author / Creator:Spurny, Radovan ; Ramerstorfer, Joachim ; Price, Kerry ; Brams, Marijke ; Ernst, Margot ; Nury, Hugues ; Verheij, Mark ; Legrand, Pierre ; Bertrand, Daniel ; Bertrand, Sonia ; Dougherty, Dennis A ; de Esch, Iwan J. P ; Corringer, Pierre-Jean ; Sieghart, Werner ; Lummis, Sarah C. R ; Ulens, Chris
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (44), p.E3028-E3034
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Allosteric and hyperekplexic mutant phenotypes investigated on an α₁ glycine receptor transmembrane structure
Author / Creator:Moraga-Cid, Gustavo ; Sauguet, Ludovic ; Huon, Christèle ; Malherbe, Laurie ; Girard-Blanc, Christine ; Petres, Stéphane ; Murail, Samuel ; Taly, Antoine ; Baaden, Marc ; Delarue, Marc ; Corringer, Pierre-Jean
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (9), p.2865-2870
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Structural basis for alcohol modulation of a pentameric ligand-gated ion channel
Author / Creator:Howard, Rebecca J ; Murail, Samuel ; Ondricek, Kathryn E ; Corringer, Pierre-Jean ; Lindahl, Erik ; Trudell, James R ; Harris, R. Adron
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (29), p.12149-12154
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The desensitization pathway of GABAA receptors, one subunit at a time

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Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry

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Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

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Short‐chain mono‐carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand‐gated ion channel, and impact of a pre‐β5 strand (Loop Ω) double mutation on crotonate, n...

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Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

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Identification of a pre-active conformation of a pentameric channel receptor

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Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

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Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

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A millisecond coarse-grained simulation approach to decipher allosteric cannabinoid binding at the glycine receptor α1

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Structural titration of receptor ion channel GLIC gating by HS-AFM

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Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors

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Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

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An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies

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One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

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Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

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A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

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Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

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Allosteric and hyperekplexic mutant phenotypes investigated on an α₁ glycine receptor transmembrane structure

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Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

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