Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine i...
Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma
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Publisher
New York: Springer US
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Language
English
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Publisher
New York: Springer US
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Contents
Purpose
Autophagy is a cell survival mechanism that plays a critical role in pancreatic carcinogenesis. Murine studies have previously demonstrated that treatment with the late-autophagy inhibitor chloroquine in combination with chemotherapy limited tumor growth.
Methods
In this phase 1/2 trial, we examined treatment with hydroxychloroquin...
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Full title
Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma
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TN_cdi_proquest_journals_1732930222
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1732930222
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ISSN
1068-9265
E-ISSN
1534-4681
DOI
10.1245/s10434-015-4566-4
