Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
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Author / Creator
Langfelder, Peter , Cantle, Jeffrey P , Chatzopoulou, Doxa , Wang, Nan , Gao, Fuying , Al-Ramahi, Ismael , Lu, Xiao-Hong , Ramos, Eliana Marisa , El-Zein, Karla , Zhao, Yining , Deverasetty, Sandeep , Tebbe, Andreas , Schaab, Christoph , Lavery, Daniel J , Howland, David , Kwak, Seung , Botas, Juan , Aaronson, Jeffrey S , Rosinski, Jim , Coppola, Giovanni , Horvath, Steve and Yang, X William
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease pathogenesis, the authors profiled mRNA in over 600 brain and peripheral tissue samples from Huntington's disease knock-in mice with increasing CAG repeat lengths. Coexpression network analyses reveal 13 striatal and 5 cortical modules that are highly...
Alternative Titles
Full title
Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
Authors, Artists and Contributors
Author / Creator
Cantle, Jeffrey P
Chatzopoulou, Doxa
Wang, Nan
Gao, Fuying
Al-Ramahi, Ismael
Lu, Xiao-Hong
Ramos, Eliana Marisa
El-Zein, Karla
Zhao, Yining
Deverasetty, Sandeep
Tebbe, Andreas
Schaab, Christoph
Lavery, Daniel J
Howland, David
Kwak, Seung
Botas, Juan
Aaronson, Jeffrey S
Rosinski, Jim
Coppola, Giovanni
Horvath, Steve
Yang, X William
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1781814816
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1781814816
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.4256
