Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Small interfering RNAs (siRNAs) conjugated to a trivalent
N
-acetylgalactosamine (GalNAc) ligand are being evaluated in investigational clinical studies for a variety of indications. The typical development candidate selection process includes evaluation of the most active compounds for toxicity in rats at pharmacologically exaggerated doses....
Alternative Titles
Full title
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2004137900
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2004137900
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-02989-4
