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In vitro measurements of protein–protein interactions show that antibody affinity governs the inhibi...

In vitro measurements of protein–protein interactions show that antibody affinity governs the inhibi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2506025506

In vitro measurements of protein–protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum

About this item

Full title

In vitro measurements of protein–protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2020-12

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Abstract The humoral immune response plays a key role in suppressing the pathogenesis of SARS-CoV-2. The molecular determinants underlying the neutralization of the virus remain, however, incompletely understood. Here, we show that the ability of antibodies to disrupt the binding of the viral spike protein to the angiotensin-converting enzyme 2 (AC...

Alternative Titles

Full title

In vitro measurements of protein–protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2506025506

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2506025506

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.12.20.422820