SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo
SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo
About this item
Full title
Author / Creator
Hou, Yixuan J , Chiba, Shiho , Halfmann, Peter , Ehre, Camille , Kuroda, Makoto , Dinnon, 3rd, Kenneth H , Leist, Sarah R , Schäfer, Alexandra , Nakajima, Noriko , Takahashi, Kenta , Lee, Rhianna E , Mascenik, Teresa M , Edwards, Caitlin E , Tse, Longping V , Boucher, Richard C , Randell, Scott H , Suzuki, Tadaki , Gralinski, Lisa E , Kawaoka, Yoshihiro and Baric, Ralph S
Publisher
United States: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
United States: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
The D614G substitution in the S protein is most prevalent SARS-CoV-2 strain circulating globally, but its effects in viral pathogenesis and transmission remain unclear. We engineered SARS-CoV-2 variants harboring the D614G substitution with or without nanoluciferase. The D614G variant replicates more efficiency in primary human proximal airway epit...
Alternative Titles
Full title
SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo
Authors, Artists and Contributors
Author / Creator
Chiba, Shiho
Halfmann, Peter
Ehre, Camille
Kuroda, Makoto
Dinnon, 3rd, Kenneth H
Leist, Sarah R
Schäfer, Alexandra
Nakajima, Noriko
Takahashi, Kenta
Lee, Rhianna E
Mascenik, Teresa M
Edwards, Caitlin E
Tse, Longping V
Boucher, Richard C
Randell, Scott H
Suzuki, Tadaki
Gralinski, Lisa E
Kawaoka, Yoshihiro
Baric, Ralph S
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2508126116
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2508126116
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.09.28.317685
