Progranulin Induces Immune Escape in Breast Cancer Via Up-Regulating PD-L1 Expression on TAMS and Pr...
Progranulin Induces Immune Escape in Breast Cancer Via Up-Regulating PD-L1 Expression on TAMS and Promoting CD8+T cell Exclusion
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Fang, Wenli , Zhou, Ting , He, Shi , Yao, Mengli , Zhang, Dian , Qian, Husun , Zeng, Qian , Wang, Yange , Jin, Fangfang , Chai, Chengsen and Chen, Tingmei
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Durham: Research Square
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English
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Durham: Research Square
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Background: Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible molecular mechanism. Methods: The changes of macrophage phenotypes after PGRN treatment were detected b...
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Progranulin Induces Immune Escape in Breast Cancer Via Up-Regulating PD-L1 Expression on TAMS and Promoting CD8+T cell Exclusion
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TN_cdi_proquest_journals_2539362273
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2539362273
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DOI
10.21203/rs.3.rs-79474/v1
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https://www.proquest.com/docview/2539362273?pq-origsite=primo&accountid=13902
