Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor
Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor
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Author / Creator
Capraz, Tuemay , Kienzl, Nikolaus F , Laurent, Elisabeth , Perthold, Jan W , Foederl-Hoebenreich, Esther , Gruenwald-Gruber, Clemens , Maresch, Daniel , Monteil, Vanessa , Niederhoefer, Janine , Wirnsberger, Gerald , Mirazimi, Ali , Zatloukal, Kurt , Mach, Lukas , Penninger, Josef M , Oostenbrink, Chris and Stadlmann, Johannes
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Infection and viral entry of SARS-CoV-2 crucially depends on the binding of its Spike protein to angiotensin converting enzyme 2 (ACE2) presented on host cells. Glycosylation of both proteins is critical for this interaction. Recombinant soluble human ACE2 can neutralize SARS-CoV-2 and is currently undergoing clinical tests for the treatment of COV...
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Full title
Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor
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TN_cdi_proquest_journals_2567807372
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2567807372
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E-ISSN
2692-8205
DOI
10.1101/2021.08.31.458325
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https://www.proquest.com/docview/2567807372?pq-origsite=primo&accountid=13902
