H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
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Author / Creator
Chen, Jiekai , Liu, He , Liu, Jing , Qi, Jing , Wei, Bei , Yang, Jiaqi , Liang, Hanquan , Chen, You , Chen, Jing , Wu, Yaran , Guo, Lin , Zhu, Jieying , Zhao, Xiangjie , Peng, Tianran , Zhang, Yixin , Chen, Shen , Li, Xuejia , Li, Dongwei , Wang, Tao and Pei, Duanqing
Publisher
New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Contents
Duanqing Pei and colleagues show that BMP signaling to histone H3 lysine 9 methylation is a barrier to reprogramming somatic cells into induced pluripotent cells (iPSCs) and that its removal promotes the formation of fully reprogrammed iPSCs from pre-iPSCs. pre-iPSCs exhibit pluripotent properties but do not activate the core pluripotent network.
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Full title
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
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TN_cdi_proquest_miscellaneous_1291606302
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1291606302
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.2491
