Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neut...
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Granulocyte-colony stimulating factor (G-CSF) promotes mobilization of CD11b ⁺Gr1 ⁺ myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models. High G-CSF production has been associated with a poor prognosis in cancer patients. Here we show that activation of the RAS/MEK/ERK pathway regulates G-CSF expression through t...
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Full title
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment
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TN_cdi_proquest_miscellaneous_1326143564
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1326143564
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1303302110
