The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip comp...
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mammalian Hedgehog (Hh) signal transduction requires a primary cilium, a microtubule-based organelle, and the Gli–Sufu complexes that mediate Hh signalling, which are enriched at cilia tips. Kif7, a kinesin-4 family protein, is a conserved regulator of the Hh signalling pathway and a human ciliopathy protein. Here we show that Kif7 localizes to the...
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The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment
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TN_cdi_proquest_miscellaneous_1542300115
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1542300115
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2988
