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Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1776656163

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

About this item

Full title

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

Publisher

London: Nature Publishing Group UK

Journal title

Nature reviews. Molecular cell biology, 2015-11, Vol.16 (11), p.665-677

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Key Points
Nonsense-mediated mRNA decay (NMD) degrades mRNAs with translation termination codons in abnormal contexts.
NMD targets mRNAs encoding truncated proteins with no or undesired functions, thereby preventing the accumulation of such transcripts and of the potentially aberrant proteins that they encode.
NMD targets some mRNAs with i...

Alternative Titles

Full title

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1776656163

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1776656163

Other Identifiers

ISSN

1471-0072

E-ISSN

1471-0080

DOI

10.1038/nrm4063

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