Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Autophagy increases the lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established
1
,
2
. Here we report lifespan and healthspan extension in a mouse model with increased basal autophagy. To determine the effects of constitutively increased autophagy on mammalian health, we generated target...
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Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
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TN_cdi_proquest_miscellaneous_2047921943
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2047921943
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0162-7
