Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
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Publisher
United States: The American Association for the Advancement of Science
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Language
English
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Publisher
United States: The American Association for the Advancement of Science
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Scope and Contents
Contents
Transforming growth factor-β1 (TGF-β1) is one of very few cytokines produced in a latent form, requiring activation to exert any of its vastly diverse effects on development, immunity, and cancer. Regulatory T cells (T
) suppress immune cells within close proximity by activating latent TGF-β1 presented by GARP (glycoprotein A repetitions predomi...
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Full title
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
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TN_cdi_proquest_miscellaneous_2126910209
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2126910209
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aau2909
