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ArticlesPeer ReviewedFull Text
Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
Author / Creator:de Streel, Grégoire ; Bertrand, Charlotte ; Chalon, Nicolas ; Liénart, Stéphanie ; Bricard, Orian ; Lecomte, Sara ; Devreux, Julien ; Gaignage, Mélanie ; De Boeck, Gitte ; Mariën, Lore ; Van De Walle, Inge ; van der Woning, Bas ; Saunders, Michael ; de Haard, Hans ; Vermeersch, Elien ; Maes, Wim ; Deckmyn, Hans ; Coulie, Pierre G. ; van Baren, Nicolas ; Lucas, Sophie
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-09, Vol.11 (1), p.4545-4545, Article 4545
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Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules
Author / Creator:Hultberg, Anna ; Temperton, Nigel J ; Rosseels, Valérie ; Koenders, Mireille ; Gonzalez-Pajuelo, Maria ; Schepens, Bert ; Ibañez, Lorena Itatí ; Vanlandschoot, Peter ; Schillemans, Joris ; Saunders, Michael ; Weiss, Robin A ; Saelens, Xavier ; Melero, José A ; Verrips, C Theo ; Van Gucht, Steven ; de Haard, Hans J
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-04, Vol.6 (4), p.e17665-e17665
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CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells
Author / Creator:Jähnichen, Sven ; Blanchetot, Christophe ; Maussang, David ; Gonzalez-Pajuelo, Maria ; Chow, Ken Y. ; Bosch, Leontien ; De Vrieze, Sindi ; Serruys, Benedikte ; Ulrichts, Hans ; Vandevelde, Wesly ; Saunders, Michael ; De Haard, Hans J. ; Schols, Dominique ; Leurs, Rob ; Vanlandschoot, Peter ; Verrips, Theo ; Smit, Martine J. ; Wells, James A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (47), p.20565-20570
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Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus?
Author / Creator:Zakrzewicz, Anna ; Würth, Celina ; Beckert, Benedikt ; Feldhoff, Simon ; Vanderheyden, Katrien ; Foss, Stian ; Andersen, Jan Terje ; Haard, Hans de ; Verheesen, Peter ; Bobkov, Vladimir ; Tikkanen, Ritva
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2022-03, Vol.11 (6), p.942
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Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies
Author / Creator:Stam, Jord C. ; de Maat, Steven ; de Jong, Dorien ; Arens, Mathia ; van Lint, Fenna ; Gharu, Lavina ; van Roosmalen, Mark H. ; Roovers, Rob C. ; Strokappe, Nika M. ; Wagner, Ralf ; Kliche, Alexander ; de Haard, Hans J. ; van Bergen en Henegouwen, Paul M. ; Nijhuis, Monique ; Verrips, C. Theo
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-08, Vol.12 (1), p.13413-13413, Article 13413
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Correction: Zakrzewicz et al. Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pe...
Author / Creator:Zakrzewicz, Anna ; Würth, Celina ; Beckert, Benedikt ; Feldhoff, Simon ; Vanderheyden, Katrien ; Foss, Stian ; Andersen, Jan Terje ; Haard, Hans de ; Verheesen, Peter ; Bobkov, Vladimir ; Tikkanen, Ritva
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2022-05, Vol.11 (10), p.1700
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Enhancement of polymeric immunoglobulin receptor transcytosis by biparatopic VHH
Author / Creator:Emmerson, Chris D ; van der Vlist, Els J ; Braam, Myrthe R ; Vanlandschoot, Peter ; Merchiers, Pascal ; de Haard, Hans J W ; Verrips, C Theo ; van Bergen en Henegouwen, Paul M P ; Dolk, Edward
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-10, Vol.6 (10), p.e26299-e26299
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Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents
Author / Creator:Riether, Carsten ; Pabst, Thomas ; Höpner, Sabine ; Bacher, Ulrike ; Hinterbrandner, Magdalena ; Banz, Yara ; Müller, Rouven ; Manz, Markus G. ; Gharib, Walid H. ; Francisco, David ; Bruggmann, Remy ; van Rompaey, Luc ; Moshir, Mahan ; Delahaye, Tim ; Gandini, Domenica ; Erzeel, Ellen ; Hultberg, Anna ; Fung, Samson ; de Haard, Hans ; Leupin, Nicolas ; Ochsenbein, Adrian F.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-09, Vol.26 (9), p.1459-1467
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ArticlesPeer ReviewedFull Text
Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans
Author / Creator:Ulrichts, Peter ; Guglietta, Antonio ; Dreier, Torsten ; van Bragt, Tonke ; Hanssens, Valérie ; Hofman, Erik ; Vankerckhoven, Bernhardt ; Verheesen, Peter ; Ongenae, Nicolas ; Lykhopiy, Valentina ; Enriquez, F Javier ; Cho, JunHaeng ; Ober, Raimund J ; Ward, E Sally ; de Haard, Hans ; Leupin, Nicolas
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2018-10, Vol.128 (10), p.4372-4386
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Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
Author / Creator:Liénart, Stéphanie ; Merceron, Romain ; Vanderaa, Christophe ; Lambert, Fanny ; Colau, Didier ; Stockis, Julie ; van der Woning, Bas ; De Haard, Hans ; Saunders, Michael ; Coulie, Pierre G ; Savvides, Savvas N ; Lucas, Sophie
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-11, Vol.362 (6417), p.952-956
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The CD70-CD27 axis in oncology: the new kids on the block
Author / Creator:Flieswasser, Tal ; Van den Eynde, Astrid ; Van Audenaerde, Jonas ; De Waele, Jorrit ; Lardon, Filip ; Riether, Carsten ; de Haard, Hans ; Smits, Evelien ; Pauwels, Patrick ; Jacobs, Julie
Publisher:England: BioMed Central Ltd
Journal title:Journal of experimental & clinical cancer research, 2022-01, Vol.41 (1), p.12-12, Article 12
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A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels
Author / Creator:Khetarpal, Sumeet A ; Zeng, Xuemei ; Millar, John S ; Vitali, Cecilia ; Somasundara, Amritha Varshini Hanasoge ; Zanoni, Paolo ; Landro, James A ; Barucci, Nicole ; Zavadoski, William J ; Sun, Zhiyuan ; de Haard, Hans ; Toth, Ildikó V ; Peloso, Gina M ; Natarajan, Pradeep ; Cuchel, Marina ; Lund-Katz, Sissel ; Phillips, Michael C ; Tall, Alan R ; Kathiresan, Sekar ; DaSilva-Jardine, Paul ; Yates, Nathan A ; Rader, Daniel J
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2017-09, Vol.23 (9), p.1086-1094
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ArticlesPeer ReviewedFull Text
The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement
Author / Creator:Brinkhaus, Maximilian ; Pannecoucke, Erwin ; van der Kooi, Elvera J. ; Bentlage, Arthur E. H. ; Derksen, Ninotska I. L. ; Andries, Julie ; Balbino, Bianca ; Sips, Magdalena ; Ulrichts, Peter ; Verheesen, Peter ; de Haard, Hans ; Rispens, Theo ; Savvides, Savvas N. ; Vidarsson, Gestur
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-10, Vol.13 (1), p.6073-6073, Article 6073
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Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies
Author / Creator:Roovers, Rob C. ; Laeremans, Toon ; Huang, Lieven ; De Taeye, Severine ; Verkleij, Arie J. ; Revets, Hilde ; de Haard, Hans J. ; van Bergen en Henegouwen, Paul M. P.
Publisher:Heidelberg: Springer Nature B.V
Journal title:Cancer Immunology, Immunotherapy, 2007-03, Vol.56 (3), p.303-317
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Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C
Author / Creator:Strokappe, Nika ; Szynol, Agnieszka ; Aasa-Chapman, Marlèn ; Gorlani, Andrea ; Forsman Quigley, Anna ; Hulsik, David Lutje ; Chen, Lei ; Weiss, Robin ; de Haard, Hans ; Verrips, Theo
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-03, Vol.7 (3), p.e33298
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VHH-Photosensitizer Conjugates for Targeted Photodynamic Therapy of Met-Overexpressing Tumor Cells
Author / Creator:Heukers, Raimond ; Mashayekhi, Vida ; Ramirez-Escudero, Mercedes ; de Haard, Hans ; Verrips, Theo C. ; van Bergen en Henegouwen, Paul. M.P. ; Oliveira, Sabrina
Publisher:Basel: MDPI AG
Journal title:Antibodies (Basel), 2019-06, Vol.8 (2), p.26
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Site-specific 68Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models
Author / Creator:Dewulf, Jonatan ; Flieswasser, Tal ; Delahaye, Tim ; Vangestel, Christel ; Miranda, Alan ; de Haard, Hans ; Jacobs, Julie ; Smits, Evelien ; Van den Wyngaert, Tim ; Elvas, Filipe
Publisher:Cham: Springer International Publishing
Journal title:EJNMMI radiopharmacy and chemistry, 2023-04, Vol.8 (1), p.8-8, Article 8
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Selection of Nanobodies that Target Human Neonatal Fc Receptor
Author / Creator:Andersen, Jan Terje ; Gonzalez-Pajuelo, Maria ; Foss, Stian ; Landsverk, Ole J. B. ; Pinto, Débora ; Szyroki, Alexander ; de Haard, Hans J. ; Saunders, Michael ; Vanlandschoot, Peter ; Sandlie, Inger
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2013, Vol.3 (1), p.1118-1118, Article 1118
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The NHance® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients
Author / Creator:Aftimos, Philippe ; Rolfo, Christian ; Rottey, Sylvie ; Barthélémy, Philippe ; Borg, Christophe ; Park, Keunchil ; Oh, Do-Youn ; Kim, Sang-We ; De Jonge, Natalie ; Hanssens, Valérie ; Zwanenpoel, Karen ; Molthoff, Carla ; Vugts, Daniëlle ; Dreier, Torsten ; Verheesen, Peter ; van Dongen, Guus A.M.S. ; Jacobs, Julie ; Van Rompaey, Luc ; Hultberg, Anna ; Michieli, Paolo ; Pauwels, Patrick ; Fung, Samson ; Thibault, Alain ; de Haard, Hans ; Leupin, Nicolas ; Awada, Ahmad
Publisher:Basel: MDPI AG
Journal title:Biomedicines, 2021-06, Vol.9 (6), p.665
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Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses
Author / Creator:Spinelli, Silvia ; Desmyter, Aline ; Verrips, C Theo ; de Haard, Hans J W ; Moineau, Sylvain ; Cambillau, Christian
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2006-01, Vol.13 (1), p.85-89
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Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer

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Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules

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CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

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Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus?

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Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies

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Correction: Zakrzewicz et al. Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pe...

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Enhancement of polymeric immunoglobulin receptor transcytosis by biparatopic VHH

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Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents

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Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans

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Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

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The CD70-CD27 axis in oncology: the new kids on the block

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A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

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The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

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Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies

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Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C

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VHH-Photosensitizer Conjugates for Targeted Photodynamic Therapy of Met-Overexpressing Tumor Cells

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Site-specific 68Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models

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Selection of Nanobodies that Target Human Neonatal Fc Receptor

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The NHance® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients

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Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses

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