Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity
Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity
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Author / Creator
Tanaka, Shinya , Ise, Wataru , Inoue, Takeshi , Ito, Ayako , Ono, Chisato , Shima, Yoshihito , Sakakibara, Shuhei , Nakayama, Manabu , Fujii, Kentaro , Miura, Ikuo , Sharif, Jafar , Koseki, Haruhiko , Koni, Pandelakis A. , Raman, Indu , Li, Quan-Zhen , Kubo, Masato , Fujiki, Katsunori , Nakato, Ryuichiro , Shirahige, Katsuhiko , Araki, Hiromitsu , Miura, Fumihito , Ito, Takashi , Kawakami, Eiryo , Baba, Yoshihiro and Kurosaki, Tomohiro
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
A contribution of epigenetic modifications to B cell tolerance has been proposed but not directly tested. Here we report that deficiency of ten–eleven translocation (Tet) DNA demethylase family members Tet2 and Tet3 in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease in mice. Mechanistically, in the ab...
Alternative Titles
Full title
Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity
Authors, Artists and Contributors
Author / Creator
Ise, Wataru
Inoue, Takeshi
Ito, Ayako
Ono, Chisato
Shima, Yoshihito
Sakakibara, Shuhei
Nakayama, Manabu
Fujii, Kentaro
Miura, Ikuo
Sharif, Jafar
Koseki, Haruhiko
Koni, Pandelakis A.
Raman, Indu
Li, Quan-Zhen
Kubo, Masato
Fujiki, Katsunori
Nakato, Ryuichiro
Shirahige, Katsuhiko
Araki, Hiromitsu
Miura, Fumihito
Ito, Takashi
Kawakami, Eiryo
Baba, Yoshihiro
Kurosaki, Tomohiro
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2416272893
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2416272893
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-020-0700-y
