Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
About this item
Full title
Author / Creator
Kinker, Gabriela S. , Greenwald, Alissa C. , Tal, Rotem , Orlova, Zhanna , Cuoco, Michael S. , McFarland, James M. , Warren, Allison , Rodman, Christopher , Roth, Jennifer A. , Bender, Samantha A. , Kumar, Bhavna , Rocco, James W. , Fernandes, Pedro A. C. M. , Mader, Christopher C. , Keren-Shaul, Hadas , Plotnikov, Alexander , Barr, Haim , Tsherniak, Aviad , Rozenblatt-Rosen, Orit , Krizhanovsky, Valery , Puram, Sidharth V. , Regev, Aviv and Tirosh, Itay
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Cultured cell lines are the workhorse of cancer research, but the extent to which they recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here we used multiplexed single-cell RNA-seq to profile 198 cancer cell lines from 22 cancer types. We identified 12 expression programs that are recurrently heterogeneous within...
Alternative Titles
Full title
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
Authors, Artists and Contributors
Author / Creator
Greenwald, Alissa C.
Tal, Rotem
Orlova, Zhanna
Cuoco, Michael S.
McFarland, James M.
Warren, Allison
Rodman, Christopher
Roth, Jennifer A.
Bender, Samantha A.
Kumar, Bhavna
Rocco, James W.
Fernandes, Pedro A. C. M.
Mader, Christopher C.
Keren-Shaul, Hadas
Plotnikov, Alexander
Barr, Haim
Tsherniak, Aviad
Rozenblatt-Rosen, Orit
Krizhanovsky, Valery
Puram, Sidharth V.
Regev, Aviv
Tirosh, Itay
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2456430683
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2456430683
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-020-00726-6
