Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes
Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes
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Author / Creator
Xu, Chunlong , Zhou, Yingsi , Xiao, Qingquan , He, Bingbing , Geng, Guannan , Wang, Zikang , Cao, Birong , Dong, Xue , Bai, Weiya , Wang, Yifan , Wang, Xiang , Zhou, Dongming , Yuan, Tanglong , Huo, Xiaona , Lai, Jinsheng and Yang, Hui
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Competitive coevolution between microbes and viruses has led to the diversification of CRISPR–Cas defense systems against infectious agents. By analyzing metagenomic terabase datasets, we identified two compact families (775 to 803 amino acids (aa)) of CRISPR–Cas ribonucleases from hypersaline samples, named Cas13X and Cas13Y. We engineered Cas13X....
Alternative Titles
Full title
Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes
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Record Identifier
TN_cdi_proquest_miscellaneous_2522191246
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2522191246
Other Identifiers
ISSN
1548-7091,1548-7105
E-ISSN
1548-7105
DOI
10.1038/s41592-021-01124-4
