In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
About this item
Full title
Author / Creator
Musunuru, Kiran , Chadwick, Alexandra C. , Mizoguchi, Taiji , Garcia, Sara P. , DeNizio, Jamie E. , Reiss, Caroline W. , Wang, Kui , Iyer, Sowmya , Dutta, Chaitali , Clendaniel, Victoria , Amaonye, Michael , Beach, Aaron , Berth, Kathleen , Biswas, Souvik , Braun, Maurine C. , Chen, Huei-Mei , Colace, Thomas V. , Ganey, John D. , Gangopadhyay, Soumyashree A. , Garrity, Ryan , Kasiewicz, Lisa N. , Lavoie, Jennifer , Madsen, James A. , Matsumoto, Yuri , Mazzola, Anne Marie , Nasrullah, Yusuf S. , Nneji, Joseph , Ren, Huilan , Sanjeev, Athul , Shay, Madeleine , Stahley, Mary R. , Fan, Steven H. Y. , Tam, Ying K. , Gaudelli, Nicole M. , Ciaramella, Giuseppe , Stolz, Leslie E. , Malyala, Padma , Cheng, Christopher J. , Rajeev, Kallanthottathil G. , Rohde, Ellen , Bellinger, Andrew M. and Kathiresan, Sekar
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Gene-editing technologies, which include the CRISPR–Cas nucleases
1
–
3
and CRISPR base editors
4
,
5
, have the potential to permanently modify disease-causing genes in patients
6
. The demonstration of durable editing in target organs of nonhuman primates is a key step before in vivo administration of gene editors to...
Alternative Titles
Full title
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
Authors, Artists and Contributors
Author / Creator
Chadwick, Alexandra C.
Mizoguchi, Taiji
Garcia, Sara P.
DeNizio, Jamie E.
Reiss, Caroline W.
Wang, Kui
Iyer, Sowmya
Dutta, Chaitali
Clendaniel, Victoria
Amaonye, Michael
Beach, Aaron
Berth, Kathleen
Biswas, Souvik
Braun, Maurine C.
Chen, Huei-Mei
Colace, Thomas V.
Ganey, John D.
Gangopadhyay, Soumyashree A.
Garrity, Ryan
Kasiewicz, Lisa N.
Lavoie, Jennifer
Madsen, James A.
Matsumoto, Yuri
Mazzola, Anne Marie
Nasrullah, Yusuf S.
Nneji, Joseph
Ren, Huilan
Sanjeev, Athul
Shay, Madeleine
Stahley, Mary R.
Fan, Steven H. Y.
Tam, Ying K.
Gaudelli, Nicole M.
Ciaramella, Giuseppe
Stolz, Leslie E.
Malyala, Padma
Cheng, Christopher J.
Rajeev, Kallanthottathil G.
Rohde, Ellen
Bellinger, Andrew M.
Kathiresan, Sekar
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2529930178
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2529930178
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03534-y
