MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell d...
MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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H3K4me1 methyltransferases MLL3 (KMT2C) and MLL4 (KMT2D) are critical for enhancer activation, cell differentiation and development. However, roles of MLL3/4 enzymatic activities and MLL3/4-mediated enhancer H3K4me1 in these processes remain unclear. Here we report that constitutive elimination of both MLL3 and MLL4 enzymatic activities prevents in...
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MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner
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TN_cdi_proquest_miscellaneous_2795358332
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2795358332
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-023-01356-4
