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Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of sene...

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of sene...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733670954

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

About this item

Full title

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Publisher

London: Nature Publishing Group UK

Journal title

Nature protocols, 2009-12, Vol.4 (12), p.1798-1806

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Normal cells can permanently lose the ability to proliferate when challenged by potentially oncogenic stress, a process termed cellular senescence. Senescence-associated beta-galactosidase (SA-βgal) activity, detectable at pH 6.0, permits the identification of senescent cells in culture and mammalian tissues. Here we describe first a cytochemical p...

Alternative Titles

Full title

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_733670954

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733670954

Other Identifiers

ISSN

1754-2189

E-ISSN

1750-2799

DOI

10.1038/nprot.2009.191

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