Induction of Direct Antimicrobial Activity through Mammalian Toll-Like Receptors
Induction of Direct Antimicrobial Activity through Mammalian Toll-Like Receptors
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Author / Creator
Thoma-Uszynski, Sybille , Stenger, Steffen , Takeuchi, Osamu , Ochoa, Maria Teresa , Engele, Matthias , Sieling, Peter A. , Barnes, Peter F. , Röllinghoff, Martin , Bölcskei, Pal L. , Wagner, Manfred , Akira, Shizuo , Norgard, Michael V. , Belisle, John T. , Godowski, Paul J. , Bloom, Barry R. and Modlin, Robert L.
Publisher
Washington, DC: American Society for the Advancement of Science
Journal title
Language
English
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Publisher
Washington, DC: American Society for the Advancement of Science
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Scope and Contents
Contents
The mammalian innate immune system retains from Drosophila a family of homologous Toll-like receptors (TLRs) that mediate responses to microbial ligands. Here, we show that TLR2 activation leads to killing of intracellular Mycobacterium tuberculosis in both mouse and human macrophages, through distinct mechanisms. In mouse macrophages, bacterial li...
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Full title
Induction of Direct Antimicrobial Activity through Mammalian Toll-Like Receptors
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Record Identifier
TN_cdi_proquest_miscellaneous_745720449
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_745720449
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.291.5508.1544
