Glutaminyl cyclase inhibition attenuates pyroglutamate Ab and Alzheimer's disease-like pathology
Glutaminyl cyclase inhibition attenuates pyroglutamate Ab and Alzheimer's disease-like pathology
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Author / Creator
Schilling, Stephan , Zeitschel, Ulrike , Hoffmann, Torsten , Heiser, Ulrich , Francke, Mike , Kehlen, Astrid , Holzer, Max , Hutter-Paier, Birgit , Prokesch, Manuela , Windisch, Manfred , Jagla, Wolfgang , Schlenzig, Dagmar , Lindner, Christiane , Rudolph, Thomas , Reuter, Gunter , Cynis, Holger , Montag, Dirk , Demuth, Hans-Ulrich and Rossner, Steffen
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Language
English
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Contents
Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Ab peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We found that the N-terminal pE-formatio...
Alternative Titles
Full title
Glutaminyl cyclase inhibition attenuates pyroglutamate Ab and Alzheimer's disease-like pathology
Authors, Artists and Contributors
Author / Creator
Zeitschel, Ulrike
Hoffmann, Torsten
Heiser, Ulrich
Francke, Mike
Kehlen, Astrid
Holzer, Max
Hutter-Paier, Birgit
Prokesch, Manuela
Windisch, Manfred
Jagla, Wolfgang
Schlenzig, Dagmar
Lindner, Christiane
Rudolph, Thomas
Reuter, Gunter
Cynis, Holger
Montag, Dirk
Demuth, Hans-Ulrich
Rossner, Steffen
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_759317525
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_759317525
Other Identifiers
ISSN
1078-8956
DOI
10.1038/nm.1872
